Fourteen chronic, frequent and 10 occasional cannabis smokers spent the night before
smoking on the clinical unit to ensure that participants were not intoxicated at the time of
smoking. Chronic, frequent users reported smoking a median (range) of 28 cannabis joints
per week (21-147), while occasional smokers reported 0.75 cannabis joints per week (0.06-
2.5). Four hundred and four paired oral fluid specimens were collected; 9 samples (2.2%)
were invalid, yielding 395 oral fluid pairs for comparison. Sensitivity, specificity and
efficiency were 66.4, 98.9, and 73.9% with the 1 ng/mL DRUID, and 75.3, 94.1, and 81.8%
with the 2 ng/mL THC proposed SAMHSA confirmation cutoffs, respectively. Sensitivity
was 6-11% higher in chronic frequent as compared to occasional cannabis smokers due to
longer detection windows and higher true positive rates. Median (range) last detection times
with the DrugTest 5000 were 12 hours (4-24) and 21 hours (1->30) for occasional and
frequent smokers, respectively (p=0.12, >30 assigned as 30 hours). Three frequent smokers’
5
Evaluation the on-site Draeger DrugTest 5000 in occasional and chronic frequent smokers following controlled
cannabis smoking
oral fluid specimens were still positive at 30 hours, but had up to 5 negative oral fluid
specimens prior to 30 hours