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"Pharmacology

GHB is rapidly absorbed with an onset of action within 15 min. Bioavailability is approximately 65%, with a half-life in blood of approximately 25 min. The drug is not protein bound in the plasma. GHB is metabolized by multiple steps ultimately to succinic acid which enters the Krebs cycle for metabolism to carbon dioxide and water. Less than 2% of GHB is eliminated unchanged in the urine, resulting in short detection times for urine screening programs of generally only 8–12 h.

GBL is more lipophilic than GHB and is absorbed faster with higher bioavailability. GBL is rapidly converted into GHB by paraoxonase enzymes found in the blood [13,14]. Levels of paraoxonase have interindividual variation, leading to significant differences in the response to GBL. 1,4BD is converted to GHB by the sequential action of alcohol dehydrogenase and aldehyde dehydrogenase, the same enzymes involved in the metabolism of ethanol and methanol [13,14]. Interindividual differences in levels of these enzymes can influence response and adverse effects of 1,4BD."


Jeg vet ikke så mye om GHB og vet ikke hvilke metabolitter som dannes i disse "multiple steps", men noen kan kanskje utdype?

Edit:

Sjekk her hvordan det brytes ned og hvilke stoffer som dannes:

https://www.wikipathways.org/index.php/Pathway:WP4157

Blå ring rundt betyr at det er en metabolitt.

Anbefaler forøvrig å droppe å erstatte alkohol med GHB hvis det er en problemstilling i ditt tilfelle Beklager på forhånd om det ikke er derfor du lurer.
Sist endret av krystallkongen; 14. september 2021 kl. 17:02. Grunn: Automatisk sammenslåing med etterfølgende innlegg.