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THC og andre cannabinoider virker ikke på egne reseptorer kalt cannabinoid reseptorer (cb1 og cb2), ikke på serotonin, dopamin og adrenalin.
kom med kilder a gutta
https://en.wikipedia.org/wiki/Tetrah...l#Pharmacology
Vis hele sitatet...
Hva slags kilde er det du egentlig oppgir? En random wikipediaside hvor det beskrives hvordan virkningene av THC blir til gjennom CB reseptorer? Javel? Her tror jeg du har linket til noe som er langt over ditt fatteevne, og at du egentlig ikke skjønner helt hva som står der. Hva er det som står der som for deg beviser at THC ikke påvirker belønningssystemet i hjernen? At du i det heletatt ber om kilder på noe som er totalt innlysende får meg ikke til å tvile ett sekund på at folk generelt sett er for dårlig opplyst når det kommer til hjernen og rus, og likevel velger å dytte i seg ting ukritisk.

"Tetrahydrokannabinol (THC) gir økt utskillelse av nevrotransmittoren dopamin i belønningssystemet i hjernen, men over tid endres baselinjen for dopaminkonsentrasjon." (https://www.mn.uio.no/ibv/tjenester/.../cannabis.html)

"The most pervasive commonality amongst noncannabinoid drugs of abuse is that they enhance electrical brain stimulation reward and act as direct or indirect dopamine agonists in the reward relevant dopaminergic projections of the medial forebrain bundle (MFB). These dopaminergic projections constitute a crucial drug sensitive link in the brain's reward circuitry, and abused drugs derive significant abuse liability from enhancing these circuits. Marijuana and other cannabinoids were long considered “anomalous” drugs of abuse, lacking pharmacological interaction with these brain reward substrates. It is now clear, however, that Δ9-tetrahydrocannab (Δ9-THC), marijuana's principal psychoactive constituent, acts on these brain reward substrates in strikingly similar fashion to noncannabinoid drugs of abuse. Specifically, Δ9-THC enhances MFB electrical brain stimulation reward, and enhances both basal and stimulated dopamine release in reward relevant MFB projection loci. Furthermore, Δ9-THC's actions on these mechanisms is naloxone blockable, and Δ9-THC modulates brain μ and δ opioid receptors. This paper reviews these data, suggests that marijuana's interaction with brain reward systems is fundamentally similar to that of other abused drugs, and proposes a specific neural model of that interaction."
(https://www.sciencedirect.com/scienc...91305791903659)

"This study shows that marijuana disrupts the natural reward circuitry of the brain, making marijuana highly salient to those who use it heavily," study author Dr. Francesca Filbey, an associate professor of behavioral and brain science at the University of Texas at Dallas, said in a statement. "In essence, these brain alterations could be a marker of transition from recreational marijuana use to problematic use." [11 Odd Facts About Marijuana]"
(https://www.livescience.com/55044-ma...rd-system.html)

https://www.youtube.com/watch?v=s27f7Jzy2k0

"Low doses had a potent anti-depressant effect, but when we increased the dose, the serotonin in the rats' brains actually dropped below the level of those in the control group. So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed."
https://www.sciencedaily.com/release...1023183937.htm

Slutt å spre idiotisk feilinformasjon. Det kan være skadelig.

"Like many drugs, marijuana in the short-term will increase the dopamine level in the brain. This happens in an indirect way. Cannabis does not purposely do this. What THC does, is bind to CB1 and CB2 receptors in the brain. Dopamine neurons do not contain any cannabinoid receptors, therefore cannabinoids cannot act directly on this. What is interesting, is that GABA neurons are used to limit the dopamine neurons in the reward pathways. But these GABA neurons do contain cannabinoid receptors which in turn inhibit them. And just like in mathematics, two negatives will equal a plus. By inhibiting what inhibits dopamine neurons, cannabinoids indirectly increase the dopamine level in the brain." (https://www.royalqueenseeds.com/blog...-dopamine-n823)
Sist endret av brennesle; 28. august 2019 kl. 08:40. Grunn: Automatisk sammenslåing med etterfølgende innlegg.