Until recently, the munchies were a relative mystery. However, a recent study by Italian scientists may explain what happens to increase appetite in marijuana users. Molecules called endocannabinoids bind with receptors in the brain and activate hunger.

This research indicates that endocannabinoids in the hypothalamus of the brain activate cannabinoid receptors that are responsible for maintaining food intake. The results of the study were published in an April 2001 issue of the scientific journal Nature.