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Comparison to benzodiazepines
Buspirone's chemical structure and mechanism of action are completely unrelated to those of the benzodiazepines, and its efficacy is not comparable to that of members of the benzodiazepine family in treating GAD.[7][8]
Buspirone shows no potential for addiction or dependence, and the development of tolerance has not been observed. Furthermore, cross-tolerance to benzodiazepines, barbiturates, and alcohol, as well as other GABAergics, is not present either. It may take several weeks before its anxiolytic effects become noticeable. Many patients may also require a higher dosage to adequately respond to treatment.[1]
In a study of diazepam and buspirone in GAD patients both drugs were effective, but buspirone took longer to take effect. Abrupt discontinuation after 6 weeks resulted in withdrawal symptoms in diazepam, which were not present with buspirone. This indicated a risk of physical dependence with diazepam, which is not present with buspirone.[9]
Buspirone is ineffective for benzodiazepine withdrawal, does not improve discontinuation rates and does not decrease the severity of withdrawal symptoms.